Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
How the surrounding environment affects the biosensing performance of Resonant Nanopillars arrays: under dry conditions or immersed in fluid
Year:2017
Research Areas
  • Optics, electromagnetism,
  • Biosensors
Information
Abstract
tIn this work we demonstrate the advantage of performing the biosensing process of a refractive indexoptical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid.We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs)arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPsin dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed asignificant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions,leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These resultsare also in good correlation with 3D-Finite difference time domain simulations carried out for both fluidconditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis willimprove the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops ofbiological samples, in dry conditions, will be a relevant issue for Point of Care Devices
International
Si
JCR
Si
Title
Sensors And Actuators B-Chemical
ISBN
0925-4005
Impact factor JCR
4,758
Impact info
Datos JCR del año 2015
Volume
10.1016/j.snb.2017.11.029
Journal number
259
From page
956
To page
962
Month
NOVIEMBRE
Ranking
Participants
  • Autor: Miguel Holgado Bolaños (UPM)
  • Autor: Ana Lopez Hernandez (UPM)
  • Autor: Rafael Casquel Del Campo (UPM)
  • Autor: Iñaki Cornago (Cemitec)
  • Autor: Fátima Fernández (Consulting Químico Sanitario S.L.)
  • Autor: Paula Ciarruz
  • Autor: Francisco Javier Sanza Gutierrez (UPM)
  • Autor: Beatriz Santamaria Fernandez (UPM)
  • Autor: Mª Victoria Maigler López (UPM)
  • Autor: Sergio Andres Quintero Moreno (UPM)
  • Autor: Maria Fe Laguna Heras (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Física Aplicada e Ingeniería de Materiales
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)