Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Changes in Phonation and Their Relations with Progress of Parkinson's Disease
Año:2018
Áreas de investigación
  • Bioinstrumentación
Datos
Descripción
Hypokinetic dysarthria, which is associated with Parkinson?s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients? voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11?26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.
Internacional
Si
JCR del ISI
Si
Título de la revista
Applied Sciences-Basel
ISSN
2076-3417
Factor de impacto JCR
1,689
Información de impacto
Volumen
DOI
10.3390/app8122339
Número de revista
Desde la página
1
Hasta la página
18
Mes
SIN MES
Ranking
Q3 77/146 Applied Physics
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Zoltan Galaz (Technical University of Brno)
  • Autor: Jiri Mekyska (Technical University of Brno)
  • Autor: Vojtech Zvoncak (Technical University of Brno)
  • Autor: Jan Mucha (Technical University of Brno)
  • Autor: Tomas Kiska (Technical University of Brno)
  • Autor: Zdenek Smekal (Technical University of Brno)
  • Autor: Ilona Eliasova (St. Anne's University Hospital Brno)
  • Autor: Martina Mrackova (St. Anne's University Hospital Brno)
  • Autor: Milena Kostalova (St. Anne's University Hospital Brno)
  • Autor: Irena Rektorova (St. Anne's University Hospital Brno)
  • Autor: Marcos Faúndez (Escola Politecnica Superior Mataró)
  • Autor: Jesús Bernardino Alonso (Universidad de Las Palmas de Gran Canaria)
  • Autor: Pedro Gomez Vilda (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Informática Aplicada al Procesado de Señal e Imagen
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos
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