Observatorio de I+D+i UPM

Memorias de investigación
Thesis:
CLOSED LOOP GLUCOSE REGULATOR USING A LINEAR TIME-VARYING LUENBERGER OBSERVER
Year:2018
Research Areas
  • Electronic technology and of the communications
Information
Abstract
We present a linear time-varying Luenberger observer (LTVLO) using compartmental models to estimate the unmeasurable states in patients with type 1 diabetes. The LTVLO proposed is based on the linearization in an operation point of the virtual patient (VP), where a linear time-varying system is obtained. LTVLO gains are obtained by selection of the asymptotic igenvalues where the observability matrix is assured. The estimation of the unmeasurable variables is done using Ackermann's methodology. The Lyapunov approach is used to prove the stability of the time-varying proposal. In order to evaluate the proposed methodology, we designed three experiments: A) VP obtained with Bergman's minimal model, B) VP obtained with Hovorka's model, and C) real patient data set. For both experiments A) and B), it is applied a meal plan to the VP, where the dynamic response of each state model is compared to the response of each variable of the time-varying observer. Once the observer is obtained in experiment B), the proposal is applied to experiment C) with data extracted from real patients and the unmeasurable state space variables are obtained with the LTVLO. LTVLO methodology has the feature of being updated each time instant to estimate the states under a known structure. The results are obtained using simulation with Matlab? and Simulink?. The LTVLO estimates the unmeasurable states from in silico patients with high accuracy by means of the update of Luenberger gains at each iteration. The accuracy of the estimated state space variables is validated through the^i parameter.
International
No
Type
Doctoral
Mark Rating
Aprobado
Date
06/07/2018
Participants
  • Director: Agustin Rodriguez Herrero (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Ingeniería Telemática y Electrónica
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)