Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
BDNF Val66Met polymorphism and gamma band disruption in resting state brain functional connectivity: A Magnetoencephalography study in cognitively intact older females
Año:2018
Áreas de investigación
  • Electrofisiología,
  • El proceso de envejecimiento
Datos
Descripción
The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ?3?3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors.
Internacional
Si
JCR del ISI
Si
Título de la revista
Frontiers in Neuroscience
ISSN
1662-453X
Factor de impacto JCR
3,877
Información de impacto
Datos JCR del año 2017
Volumen
684
DOI
10.3389/fnins.2018.00684
Número de revista
12
Desde la página
684
Hasta la página
684
Mes
OCTUBRE
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Inmaculada Concepción Rodríguez-Rojo (Universidad Complutense de Madrid)
  • Autor: Pablo Cuesta Prieto (UPM)
  • Autor: Jaisalmer de Frutos Lucas (Universidad Autónoma de Madrid)
  • Autor: Ricardo Bruña Fernandez (UPM)
  • Autor: Ernesto Pereda De Pablos (UPM)
  • Autor: Ana Barabash
  • Autor: Pedro Montejo
  • Autor: Alberto Marcos
  • Autor: Alberto Fernández Lucas (UPM)
  • Autor: Ramón López Higues
  • Autor: Fernando Maestu Unturbe (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
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