Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Impact of APOE2 allele on lipid profile change after a weight loss program
Year:2018
Research Areas
  • Physiology,
  • Physiology of exercise,
  • Health
Information
Abstract
BACKGROUND: apolipoprotein E (ApoE) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. OBJECTIVE: to evaluate the impact of ApoE2allele in lipid plasma levels and the influence of a healthy hypocaloric diet plus a controlled physical activity on the lipid profile, we performed a study in a cohort of overweight and obese healthy subjects (Body Mass Index (BMI) between 25 and 34.9 kg·m-2). METHODS: one hundred eighty participants (96 women), aged 18-50 years participated in a 22 weeks weight loss intervention based on same dietary treatment and different controlled exercise programs. All subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure). Blood samples were obtained for lipids measurements at the beginning and end of the study. RESULTS: after intervention, men of the E2 group showed the greatest decreases in low-density lipoprotein (LDL), triglycerides (TG) and total cholesterol (TC) values (p = 0.039; p = 0.001; p = 0.001; respectively). For high-density lipoprotein (HDL), E2 group had significant differences compared with E4 at pre- (p = 0.020) and post-intervention values (p = 0.024). CONCLUSION: our results show great changes in men carrying ApoE2, mainly in TG and TC concentrations after treatment with hypocaloric diet and controlled exercise. Therefore, adding supervised training to nutritional intervention seems to be a good alternative for the reinforcement of the effect of the treatment.
International
Si
JCR
Si
Title
Nutricion Hospitalaria
ISBN
0212-1611
Impact factor JCR
0,747
Impact info
Volume
35
10.20960/nh.1278
Journal number
2
From page
305
To page
311
Month
SIN MES
Ranking
Participants
  • Autor: Rocio Cupeiro Coto (UPM)
  • Autor: Fco. Javier Calderon Montero (UPM)
  • Autor: Ana Belen Peinado Lozano (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Investigación del Laboratorio de Fisiología del Esfuerzo.
  • Departamento: Salud y Rendimiento Humano
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