Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
A New Device Based on Interferometric Optical Detection Method for Label-Free Screening of C-Reactive Protein
Year:2018
Research Areas
  • Biosensors
Information
Abstract
In previous work, the performance of a compact and cost-effective point-of-care (PoC) device based on the increase relative optical power (IROP) methodology is reported and it is determined the enhancement in comparison with standard high-resolution spectrometry in terms of limit of detection. This paper describes a new label-free IROP-based biomedical device capable of working with low concentration of reagents and low sample volume per measurement in order to be used for screening different steps necessary in immunoassay optimization. This new approach significantly improves the sensing performance in terms of read-out signal (?IROP) per nanometer of biofilm in comparison with our previous work. This improvement is achieved due to the implementation of a laser as light source of the optical read-out system and the redesign of Fabry?Perot transducers by optimizing their reflectivity response and reducing their sensing area. For demonstrating the screening capability of this new PoC device in several immunoassays steps and methodologies, a C-reactive protein detection assay was carried out as a potential application and assay model. It is remarkable that only 10 ?L of sample was used per measurement. This labelfree IROP-based device complies an easy-to-use and cost-effective tool for immunoassays optimization in terms of performance, reagents cost, and measuring time.
International
Si
JCR
Si
Title
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
ISBN
1557-9662
Impact factor JCR
Impact info
Volume
10.1109/TIM.2018.2876073
Journal number
From page
1
To page
7
Month
SIN MES
Ranking
Participants
  • Autor: Mª Victoria Maigler López (UPM)
  • Autor: Rocio Lopez Espinosa (UPM)
  • Autor: Alvaro Lavin Hueros (UPM)
  • Autor: Miguel Holgado Bolaños (UPM)
  • Autor: Maria Fe Laguna Heras (UPM)
  • Autor: Francisco Javier Sanza (BIOD SL)
  • Autor: Beatriz Santamaria Fernandez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Óptica Fótonica y Biofotónica (GOFB)
  • Centro o Instituto I+D+i: Centro Laser
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Física Aplicada e Ingeniería de Materiales
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)