Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
The major milk allergen Bos d 5 prevents allergic sensitization in the mouse model only when loaded with quercetin-iron: Role for the aryl hydrocarbon receptor pathway
Year:2018
Research Areas
  • Natural sciences and health sciences,
  • Molecular, cellular and genetic biology
Information
Abstract
The major milk allergen Bos d 5 is a lipocalin and can be loaded with quercetin, a flavonoid with a great affinity to iron. We previously demonstrated in vitro that the loading of Bos d 5 with such a ligand is decisive for induction of immune tolerance. Here, we addressed the in vivo relevance of this observation by nasal allergic sensitization of BALB/c mice using unloaded (apo?) or quercetin?iron?loaded (holo?) Bos d 5, and further elucidated a potential mechanistic role of the aryl hydrocarbon receptor (AhR) pathway.
International
Si
Congress
European Academy of Allergy and Clinical Immunology (EAACI), congress 2018.
960
Place
Reviewers
Si
ISBN/ISSN
0105-4538
Start Date
26/05/2018
End Date
30/05/2018
From page
17
To page
17
Special Issue:Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26?30 May 2018, Munich, Germany
Participants
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: F Roth-Walter
  • Autor: M Afify
  • Autor: K Kienast
  • Autor: A Vidovic
  • Autor: I Pali-scholl
  • Autor: Z Dvorak
  • Autor: E Jensem-Jarolim
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología - Biología Vegetal
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