Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
LIFT bioprinting for the study of the immune response
Year:2018
Research Areas
  • Biomedicine,
  • Mechanical aeronautics and naval engineering,
  • Mechanical engineering
Information
Abstract
Immunology is a transversal field that is governed by a complex network of genetic and signalling pathways subtending a network of interacting cells. Laser bioprinting is a powerful tool to study complex biological systems like the ones that govern the immune response. The high accuracy and non-destructive nature of LIFT (Laser Induced Forward Transfer) is applied to the study of cell-cell interaction. In particular, single cell laser bioprinting helps to understand the relationship between the cell and their local environment. In this context, mobility of the cells in a network, along with their situation and the gene products they interact with, plays an important role in the behaviour of the immune system. In this work, we use a laser induced forward transfer blister assisted (BALIFT) approach to assess these cell-cell interactions in vitro. This method helps to understand properly the role of a cell within a network to increase our knowledge of the immune system response. This work presents BALIFT bioprinting of single hematopoietic cells with high spatial resolution. In particular, NK cells (natural killer) and T-lymphocyte are printed in different laser conditions and specific patterns to study cell viability and cell-cell interaction. By means of this technique, we can place cellular components on a previously designed matrix, allow us to test the molecular interactions between lymphocytes and pathogens.
International
Si
Congress
Annual Meeting of the International Society for Biofabrication 2018
970
Place
Würzburg Alemania
Reviewers
Si
ISBN/ISSN
00000000
Start Date
28/10/2018
End Date
31/10/2018
From page
1
To page
1
http://www.biofabrication2018.org/wp-content/uploads/2018/10/ProgrammISBF_Web.pdf
Participants
  • Autor: Sara Lauzurica Santiago (UPM)
  • Autor: Andrés Márquez Fernández (UPM)
  • Autor: Carlos Luis Molpeceres Alvarez (UPM)
  • Autor: L Notario (Instituto de Salud Carlos III)
  • Autor: Miguel Gómez Fontela (UPM)
  • Autor: P Lauzurica (Instituto de Salud Carlos III)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Manufactura Avanzada con Láser
  • Centro o Instituto I+D+i: Centro Laser
  • Departamento: Física Aplicada e Ingeniería de Materiales
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