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Memorias de investigación
Communications at congresses:
Integrative transcriptome analysis reveals the gene expression networks underlying the sulfate response in arabidopsis thaliana
Year:2018
Research Areas
  • Biological sciences
Information
Abstract
Sulfur is an essential nutrient for plant growth and development. Sulfur is a constituent of proteins, the plasma membrane and cell walls, among other important cellular components. To obtain new insights into the gene regulatory networks underlying the sulfate response, we performed an integrative meta-analysis of transcriptomic data from five different sulfate experiments available in public databases. This bioinformatic approach allowed us to identify a robust set of genes whose expression depends only on sulfate availability, indicating that those genes play an important role in the sulfate response. In relation to sulfate metabolism, the biological function of approximately 45% of these genes is currently unknown. Moreover, we found several consistent Gene Ontology terms related to biological processes that have not been extensively studied in the context of the sulfate response; these processes include cell wall organization, carbohydrate metabolism, nitrogen compound transport, and the regulation of proteolysis. Gene co-expression network analyses revealed relationships between the sulfate-responsive genes that were distributed among seven function-specific co-expression modules. The most connected genes in the sulfate co-expression network belong to a module related to the carbon response, suggesting that this biological function plays an important role in the control of the sulfate response. Temporal analyses of the network suggest that sulfate starvation generates a biphasic response, which involves that major changes in gene expression occur during both the early and late responses. Network analyses predicted that the sulfate response is regulated by a limited number of transcription factors, including MYBs, bZIPs, and NF-YAs. In conclusion, our analysis identified new candidate genes and provided new hypotheses to advance our understanding of the transcriptional regulation of sulfate metabolism in plants.
International
Si
Congress
INTERNATIONAL PLANT MOLECULAR BIOLOGY 2018
970
Place
Montpelier, Francia
Reviewers
Si
ISBN/ISSN
0000-0000
Start Date
05/08/2018
End Date
10/08/2018
From page
0
To page
0
INTERNATIONAL PLANT MOLECULAR BIOLOGY 2018
Participants
  • Autor: Joaquin Medina Alcazar (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
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