Observatorio de I+D+i UPM

Memorias de investigación
Conferences:
LASER DIRECT WRITING OF BIOCOMPATIBLE HYDROGELS USING A BLISTER ASSISTED APPROACH WITH THICK POLYIMIDE LAYERS
Year:2018
Research Areas
  • Biomedicine,
  • Mechanical aeronautics and naval engineering,
  • Mechanical engineering
Information
Abstract
Laser Direct Write techniques for printing applications of living material is currently a hot topic in different biomedical and engineering fields like tissue engineering, drug delivery, biosensing, etc. specialized groups in the field have been done to find and control the ideal conditions of printability, in order to maintaining unchanged the properties of the biological transferred material. In this work we present a comprehensive study of the printability map of two of the most used biocompatible hydrogels, Sodium Alginate and Methylcellulose. We discuss the effect of hydrogel density, laser parameters influence, etc. using a blister assisted laser writing technique. In our approach we use a thick polyamide layer for blister generation, this presents huge advantages to limit the direct laser irradiation of the living material to be transferred. In addition the physics of blister dynamics and droplet-jet formation is discussed by means of a combined study using numerical modeling of the process fluid dynamics and high speed imaging of the transfer. Finally a particular example of advantages of the approach from the biological point of view is discussed presenting a cell viability study of Jurkat cell printing in the conditions discussed in the study
International
Si
9781510615250
Entity
SPIE
Entity Nationality
E.E.U.U. DE AMERICA
Place
San Francisco
Participants
  • Autor: Carlos Luis Molpeceres Alvarez (UPM)
  • Autor: Andrés Márquez Fernández (UPM)
  • Autor: Sara Lauzurica Santiago (UPM)
  • Autor: David Muñoz Martin (UPM)
  • Autor: Juan Jose Moreno Labella (UPM)
  • Autor: Miguel Morales Furio (UPM)
  • Autor: Miguel Gómez Fontela (UPM)
  • Autor: P Lauzurica (Instituto de Salud Carlos III)
Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro Laser
  • Departamento: Física Aplicada e Ingeniería de Materiales
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)