Observatorio de I+D+i UPM

Memorias de investigación
Proyecto de I+D+i:
BITFORM: Multiplexed biosensing and tissue-on-a-chip integrated platform for breast cancer biomarkers monitoring
Año:2019
Áreas de investigación
Datos
Descripción

In this project I will develop an integrated multi-module platform in which a breast cancer ecosystem-on-a-chip (BCE-on-a-chip) bioreactor module, connected to an optical biosensing module based on multiplexed Resonant Nanopillars (R-NPs) transducers, will be developed for biomarkers and anti-breast cancer drug real-time monitoring.

Currently attrition rates in clinical trials for new anti-cancer drugs and personalized treatments are higher than all other therapeutic areas. Mainly due to the great reliability on conventional 2D and 3D scaffolds in-vitro culture methodologies in preclinical studies. Those cell-based models are limited by their¿ inability to conserve the patient tumor features and do not accurately show drug response, observed later in clinical trials.

Due to the increasing number of cancer diagnoses, an engineered system that allows an accurate prediction of patient tumor response to anti-cancer drug, is urgently needed.

In Bitform Project I will develop a BCE-on-a-chip bioreactor that intends to conserve the cancer tissue characteristics with high reliability. Breast cancer cell secreted biomarkers will be monitored in real-time with a multiplexed biosensing module based on R-NPs. In order to assess the capability of Bitform platform, an anti-cancer drug demonstrator (Paclitaxel) will be tested. By delivering Paclitaxel to the BCE-on-a-chip, monitoring of different cell secreted target biomarkers will permit to evaluate the effect of this drug, and thus to demonstrate the performance of the platform.

The Bitform platform will be suitable for different organ-on-chip culture models and biomolecules monitoring secreted by the cells. This will lead to a new methodology for testing anti-cancer therapies on-a-chip. This is a relevant milestone to study the further potential of the Bitform Platform in personalized medicine, which can have a transformative impact not only on the outcome but also on the costs of treatments by avoiding expensive failures.

Internacional
Si
Tipo de proyecto
Proyectos y convenios en convocatorias públicas competitivas
Entidad financiadora
Nacionalidad Entidad
Sin nacionalidad
Tamaño de la entidad
Fecha concesión
02/04/2019
Esta actividad pertenece a memorias de investigación
Participantes
  • Director: Miguel Holgado Bolaños (UPM)
  • Participante: Ana Lopez Hernandez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: No seleccionado
  • Grupo de Investigación: Grupo de Óptica Fótonica y Biofotónica (GOFB)
  • Departamento: Física Aplicada e Ingeniería de Materiales
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2022 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)