Descripción
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In this work we propose an image registration algorithm to automatically fit protein atomic domain models into medium-resolution three-dimensional electron microscopy reconstructions (3D-EM map). The approach employs a flexible registration algorithm whose optimizer controls the generation of stereo-chemically correct models from a given reference domain belonging to a super-family of proteins. The proposed algorithm generates models automatically in the correct direction until the optimizer converges to the best fitted model. A local gradient optimizer is employed for this task. Mutual Information is used as an alternative to Cross Correlation Coefficient. An additional rigid registration that uses a local gradient optimization is applied between each generated model and the 3D-EM map. | |
Internacional
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Si |
Nombre congreso
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5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) |
Tipo de participación
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960 |
Lugar del congreso
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Paris |
Revisores
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Si |
ISBN o ISSN
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978-1-4244-2003-2 |
DOI
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Fecha inicio congreso
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14/05/2008 |
Fecha fin congreso
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17/05/2008 |
Desde la página
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983 |
Hasta la página
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986 |
Título de las actas
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Proceedings of 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. |