Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
Flexible Image Registration for the Identification of Best Fitted Protein Models in 3D-EM Maps
Year:2008
Research Areas
  • Electronics engineering
Information
Abstract
In this work we propose an image registration algorithm to automatically fit protein atomic domain models into medium-resolution three-dimensional electron microscopy reconstructions (3D-EM map). The approach employs a flexible registration algorithm whose optimizer controls the generation of stereo-chemically correct models from a given reference domain belonging to a super-family of proteins. The proposed algorithm generates models automatically in the correct direction until the optimizer converges to the best fitted model. A local gradient optimizer is employed for this task. Mutual Information is used as an alternative to Cross Correlation Coefficient. An additional rigid registration that uses a local gradient optimization is applied between each generated model and the 3D-EM map.
International
Si
Congress
5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008)
960
Place
Paris
Reviewers
Si
ISBN/ISSN
978-1-4244-2003-2
Start Date
14/05/2008
End Date
17/05/2008
From page
983
To page
986
Proceedings of 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro.
Participants
  • Participante: Carlos O.S. Sorzano (CSIC, Madrid)
  • Participante: Jose Mª Carazo (CSIC, Madrid)
  • Autor: Andres de Santos Lleo (UPM)
  • Participante: Laura Fernandez de Manuel (UPM)
  • Autor: Maria Jesus Ledesma Carbayo (UPM)
  • Participante: J. Atineza Herrero (CSIC, Madrid)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Ingeniería Electrónica
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)