Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
In-vivo estimation of the axonal radius in directionally heterogeneous tissues
Year:2008
Research Areas
  • Electronics engineering
Information
Abstract
Diffusion MRI is a powerful methodology for the measurement of the diffusional motion of water molecules in tissue. The most outstanding and promising applications of dMRI belong to the field of brain research and clinical practice (brain mapping, connectivity and tractography algorithms development, ischemia diagnosis, early evidences of pathologies such as schizophrenia and Alzheimer¿s disease...). Although its background lies on the random Brownian motion due to thermal energy, the underlying tissue microstructure yields anisotropic diffusion, so that this technique provides useful information about the tissue geometric organization and composition, which determines the scatter pattern of water particles in tissue, as it is well documented ([1-2]). Recent models have attempted to relate both the self¿diffusion of water molecules and the underlying white matter microstructural features, where the orientation of the axonal bundles is assumed to be known a priori. It limits the application field to ex¿vivo experiments. Here we approach an extension on a former model by including directional heterogeneity in the axonal distribution based on a spherical harmonic decomposition of the fibres orientation distribution function (ODF).
International
Si
Congress
12th Congress of the European Federation of Neurological Societies
960
Place
Madrid
Reviewers
Si
ISBN/ISSN
1351-5101
Start Date
23/08/2008
End Date
26/08/2008
From page
299
To page
299
European Journal of Neurology, vol. 15, suppl. 3
Participants
  • Participante: Saad Jbabdi (University of Oxford, UK)
  • Autor: Rosario Sance Garzón (UPM)
  • Autor: Maria Jesus Ledesma Carbayo (UPM)
  • Autor: Andres de Santos Lleo (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Ingeniería Electrónica
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
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