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Descripción
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| Although developmental biology has identified numerous genes involved in embryogenesis processes, we are largely unable so far to understand the spatio-temporal dynamics of gene expression in the context of cell morphodynamics. A first step in what would be a complex systems approach of this question is to achieve the reconstruction of genetic networks with the appropriate spatial and temporal resolution. Genetic networks are traditionally schematized as blocks diagrams that represent causal interactions between genes. However, this kind of representation is largely insufficient for describing and further modelling the spatio temporal dynamics underlying embryogenetic processes. What we need here is a representation of where and when at the cellular level genes are expressed. We aim in this project at designing a methodology for reconstructing and modeling the dynamics of the gene network at play during the formation of the dorsal endomesoderm in the early zebrafish embryo. This process takes place during the first 6 hours post fertilization (at 28°C) when the embryo develops from 1 to 5000 cells. The molecular genetics of this system has been extensively studied. However, published data does not allow to properly reconstruct the corresponding genetic network and we are very far from understanding how the gene expression dynamics and cell morphodynamics are coupled. | |
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Internacional
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Si |
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Tipo de proyecto
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Proyectos y convenios en convocatorias públicas competitivas |
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Entidad financiadora
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Ministerio Ciencia e Innovacion |
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Nacionalidad Entidad
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ESPAÑA |
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Tamaño de la entidad
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Desconocido |
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Fecha concesión
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01/01/2008 |