Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity
Year:2009
Research Areas
  • Microbiology
Information
Abstract
The leishmanicidal activity of plant antibiotic peptides (PAPs) from the principal families, such wheat thionins, a barley lipid transfer protein and potato defensins and snakins were tested in vitro against Leishmania donovani. Only thionins and defensins were active against this human pathogen at a low micromolar range of concentrations. Thionins resulted as the most active peptides tested until now. They collapsed ionic and pH gradients across the parasite plasma membrane together with a rapid depletion of intracellular ATP without affecting mitochondrial potential. Hence the lethal effect of thionins was mostly associated to permeabilization of the plasma membrane leading to an immediate death of the parasite. The present work is the first evidence for leishmanicidal activity in plant peptides. Future prospects for their development as new antiparasite agents on human diseases are considered.
International
Si
JCR
Si
Title
EXPERIMENTAL PARASITOLOGY
ISBN
0014-4894
Impact factor JCR
1,751
Impact info
Volume
122
Journal number
0
From page
247
To page
249
Month
ENERO
Ranking
Participants
  • Autor: Pablo Rodriguez Palenzuela (UPM)
  • Autor: Antonio Molina Fernandez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Interacciones Moleculares Planta-Patógeno
  • Departamento: Biotecnología
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
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