Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.
Year:2010
Research Areas
  • Health
Information
Abstract
Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on functional connectivity patterns. Networks were calculated from resting-state magnetoencephalographic recordings from 15 brain injured patients and 14 healthy controls by means of wavelet coherence in standard frequency bands. We compared the parameters defining the network, such as number and strength of interactions as well as their topology, in controls and patients for two conditions: following a traumatic brain injury and after a rehabilitation treatment. A loss of delta- and theta-based connectivity and conversely an increase in alpha- and beta-band-based connectivity were found. Furthermore, connectivity parameters approached controls in all frequency bands, especially in slow-wave bands. A correlation between network reorganization and cognitive recovery was found: the reduction of delta-band-based connections and the increment of those based on alpha band correlated with Verbal Fluency scores, as well as Perceptual Organization and Working Memory Indexes, respectively. Additionally, changes in connectivity values based on theta and beta bands correlated with the Patient Competency Rating Scale. The current study provides new evidence of the neurophysiological mechanisms underlying neuronal plasticity processes after brain injury, and suggests that these changes are related with observed changes at the behavioural level.
International
Si
JCR
No
Title
Brain : a journal of neurology
ISBN
0006-8950
Impact factor JCR
0
Impact info
Volume
133
Journal number
8
From page
2365
To page
2381
Month
AGOSTO
Ranking
Participants
  • Autor: Nazareth Perales Castellanos (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)