Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Functional connectivity in mild cognitive impairment during a memory task: implications for the disconnection hypothesis.
Year:2010
Research Areas
  • Health
Information
Abstract
Abstract.Mild cognitive impairment (MCI) has been considered an intermediate state between healthy aging and dementia. The early damage in anatomical connectivity and progressive loss of synapses that characterize early Alzheimer¿s disease suggest that MCI could also be a disconnection syndrome. Here, we compare the degree of synchronization of brain signals recorded with magnetoencephalography from patients (22) with MCI with that of healthy controls (19) during a memory task. Synchronization Likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. During the memory task patients showed higher interhemispheric synchronization than healthy controls between left and right anterior temporofrontal regions (in all studied frequency bands) and in posterior regions in the band. On the other hand, the connectivity pattern from healthy controls indicated two clusters of higher synchronization, one among left temporal sensors and another one among central channels. Both of them were found in all frequency bands. In the band, controls showed higher Synchronization Likelihood values than MCI patients between centralposterior and frontalposterior channels and a high synchronization in posterior regions. The interhemispheric increased synchronization values could reflect a compensatory mechanism for the lack of efficiency of the memory networks in MCI patients. Therefore, these connectivity profiles support only partially the idea of MCI as a disconnection syndrome, as patients showed increased long distance interhemispheric connections but a decrease in anteroposterior functional connectivity.
International
Si
JCR
Si
Title
JOURNAL OF ALZHEIMERS DISEASE
ISBN
1387-2877
Impact factor JCR
3,832
Impact info
Volume
22
Journal number
1
From page
183
To page
193
Month
ENERO
Ranking
Participants
  • Autor: Nazareth Perales Castellanos (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)