Descripción
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Monocarboxylate Transporter1(MCT1)mediatesthetransportofthemainfractionoflactateacrossthesarcolemma.Acommonpolymor- phic MCT1varianthasbeenidentified,butitsroleinhighintensityexerciseperformancehasnotbeendefined.Weinvestigatedtheinfluence of MCT1A1470Tpolymorphism(rs1049434)onlactateaccumulationafterhighintensitycircuittraining.Tenmenaged20¿26performed three controlledcircuittraining(CWT)sessionsat60%,70%,and80%ofthe15repetitionmaximum(15RM),innon-consecutivedays. CWT includedthreesetsofacircuitofeightexercises,obtaininglactatemeasurementsimmediatelyaftereachsethadbeencompleted.Two independent variableswereanalysed:MTC1genotypesaccordingtothepresenceorabsenceoftheA1470Tpolymorphism,andtheintensity of circuittraining.GenotypedistributionswereinHardy¿Weinbergequilibrium,being30%wild-type,50%heterozygotes,and20%mutated homozygotes. Meanlactateconcentrationat80%of15RMweresignificantlyhigherthanthemeanlactatevaluesattheotherintensities (p < 0.01).Significantdifferencesbetweengeneticgroupswerefoundinthelactateaccumulationslopeat80%of15RM(p = 0.02)andinthe maximal lactateconcentrationreachedbyallsubjectsinthestudy(Lmax) (p = 0.03).ThecarriersoftheA1470TpolymorphismintheMTC1 gene seemtoexhibitaworselactatetransportcapabilityintothelessactivemusclecellsforoxidation. © 2009SportsMedicineAustralia.PublishedbyElsevierLtd.Allrightsreserved. | |
Internacional
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Si |
JCR del ISI
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Si |
Título de la revista
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JOURNAL OF SCIENCE AND MEDICINE IN SPORT |
ISSN
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1440-2440 |
Factor de impacto JCR
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1,57 |
Información de impacto
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Volumen
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DOI
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10.1016/j.jsams.2009.07.004 |
Número de revista
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Desde la página
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526 |
Hasta la página
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530 |
Mes
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ENERO |
Ranking
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