Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study
Year:2010
Research Areas
  • Natural sciences and health sciences
Information
Abstract
Monocarboxylate Transporter1(MCT1)mediatesthetransportofthemainfractionoflactateacrossthesarcolemma.Acommonpolymor- phic MCT1varianthasbeenidentified,butitsroleinhighintensityexerciseperformancehasnotbeendefined.Weinvestigatedtheinfluence of MCT1A1470Tpolymorphism(rs1049434)onlactateaccumulationafterhighintensitycircuittraining.Tenmenaged20¿26performed three controlledcircuittraining(CWT)sessionsat60%,70%,and80%ofthe15repetitionmaximum(15RM),innon-consecutivedays. CWT includedthreesetsofacircuitofeightexercises,obtaininglactatemeasurementsimmediatelyaftereachsethadbeencompleted.Two independent variableswereanalysed:MTC1genotypesaccordingtothepresenceorabsenceoftheA1470Tpolymorphism,andtheintensity of circuittraining.GenotypedistributionswereinHardy¿Weinbergequilibrium,being30%wild-type,50%heterozygotes,and20%mutated homozygotes. Meanlactateconcentrationat80%of15RMweresignificantlyhigherthanthemeanlactatevaluesattheotherintensities (p < 0.01).Significantdifferencesbetweengeneticgroupswerefoundinthelactateaccumulationslopeat80%of15RM(p = 0.02)andinthe maximal lactateconcentrationreachedbyallsubjectsinthestudy(Lmax) (p = 0.03).ThecarriersoftheA1470TpolymorphismintheMTC1 gene seemtoexhibitaworselactatetransportcapabilityintothelessactivemusclecellsforoxidation. © 2009SportsMedicineAustralia.PublishedbyElsevierLtd.Allrightsreserved.
International
Si
JCR
Si
Title
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
ISBN
1440-2440
Impact factor JCR
1,57
Impact info
Volume
10.1016/j.jsams.2009.07.004
Journal number
From page
526
To page
530
Month
ENERO
Ranking
Participants
  • Autor: Rocio Cupeiro Coto (UPM)
  • Autor: Pedro Jose Benito Peinado (UPM)
  • Autor: Fco. Javier Calderon Montero (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Ejercicio Físico, Salud y sus Fundamentos Fisiológicos (EFISAF)
  • Departamento: Salud y Rendimiento Humano
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)