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Briefing

Thrombectomy device for removal of arterial blockages through aspiration

 A stroke disease occurs when blood flow of part of the brain stops, in case of more than a few seconds, the brain can not get blood and oxygen, causing permanent damage. According to WHO, more than 17M people die from cerebrovascular disease. Only in the U.S. affects more than 700000 Americans each year, causing 150000 deaths and remains the leading cause of disability in adults and the third leading cause of death. In Spain, strokes are the leading cause of death in women, one of the neurological diseases of greater social impact, with 130.000 new cases each year.

Ischemic stroke occurs when a blood vessel supplying blood to the brain is blocked by a blood clot. Treatments for such accidents can be divided in chemical and mechanical thrombectomy devices. The decision to develop a new device which allows effectively eliminate the presence of these clots, lies in the high percentage of population affected and the various risks found when performing an analysis of the situation today.

 
Technology Solution

The purposes of any mechanical thrombectomy device can be summarized in effecting the removal of the clot formed inside of the artery and restoring blood flow from the artery. From recent years, numerous devices have been developed, many of them operating at the periphery of the vascular system, however, relatively few have been used in the cerebral vasculature. One of the main problems of these devices is that they can produce embolisms or breaks downstream of the arterial walls due to their moving parts.

As a result, there is a need to design a device based on aspiration, without moving parts, with a simple design, and that can act as an effective remover of blood clots without causing possible embolisms due to the breakage of the blood clot.

“ Simple, practical and effective”

 
Market demands

  • In recent years it has grown the number of solutions developed for the purpose stated herein - more than hundred - not existing a common denominator to all of them. Some devices rely on clot perforation; other, however are based on the trapping of the blood clot through the use of deformable elements, called stents.
  • After analysis of different commercial solutions have been seen different turning points and the need to develop a product that involves less risk to the patient, shorter, both preparation and use, and lower production costs.
  • If we analyze almost all existing devices, we observe there is a great possibility of creating disintegrations of the main blood clot, which could cause future problems in smaller arteries. Moreover, the existence of different moving parts make the manufacturing cost be high (300 ÷ 3000 €/unit) and that the risk involved in handling or operating methodology be inherent.
  • The correct optimization would be carried out by means of simulation techniques and would require greater engagement between medical and engineers to, on the one hand, correctly analyze the formation process of the blood clot and, secondly, develop the device.

 
Market potential

Given the limitations in the use of the device described here, the existing market potential was estimated from three main areas:

  • Large percentage of population affected
  • Sector 'Health', with continuing need for finding new solutions and means to do so
  • Problems found in the competence.

This potential can be seen from the large number of thrombectomy devices developed in recent years, which shows the concern in the sector, the continuing need for innovation and the growing interest of the different laboratories

 
Competitive advantages

  • Devices such as SOLITAIRE or MERCI, despite its proven success, contain mechanical parts based on the use of stents, resulting in the possible rupture of the artery or the blood clot.
  • The extraction device recently designed in UK and called 'GP' contemplates idealized features here, but nevertheless has been seen after numerous analysis how the existence of a return on the suction or a constant distance to the clot makes it unavailable for use in some cases. The fact of no moving parts provides a starting point for the development of a new device that involves  fewer risks and higher effectiveness.
  • It have been developed simulation models; it remains to make a more realistic sizing of these prototypes and laboratory verification.
 
References

  • Several articles published in international journals and conferences, having received an invitation from a prestigious American publishing house for editing a book to analyze thoroughly the problems encountered.
 
Development stage

  • Concept
  • R & D
  • Lab Prototype
  • Industrial Prototype
  • Production
 
Contact

Contact GPR

Gregorio Romero

CITEF. Railway Technologies Investigation Center

e: gregorio.romero@upm.es

w:www.citef.industriales.upm.es

 

UPM  contact

Innovation, Commercialization and Entrepreneurship Area

Centre of Support for Technological Innovation – UPM

e: innovacion.tecnologica@upm.es

 
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