REMOTE aims at defining and establishing a multidisciplinary and integrated approach to Research & Development (R&D) of Information & Communication Technology (ICT) for addressing, in real life contexts, identified needs of frail elderly, especially of citizens at risk due to geographic and social isolation in combination with chronic conditions, such as hypertension, arthritis, asthma, stroke, Alzheimer´s disease (AD), and Parkinson¿s disease (PD), and the coexistence of lifestyle risk factors, such as obesity, blood pressure, smoking, alcohol abuse, poor eating/drinking habits, stress, and low levels of physical activity. The project will advance the state-of-the-art in fields of tele-healthcare and ambient intelligence (AmI) by enhancing the elderly¿s personal environment with audio-visual, sensor/motoric monitoring, and automation abilities for tracing vital signs, activity, behaviour and health condition, and detecting risks and critical situations, as well as providing, proactively and reactively, effective and efficient support at home. To this end, scale-up of existing research prototypes and development of new systems for collecting human- and context-related data will be deployed in the course of the project. These include, on the one hand, wearables and sensors for detecting intra-oral miniature wetness and jaw movements, body temperature, blood pressure, heart rate, human posture and motion / acceleration recognition, etc., and, on the other hand, sensors and actuators to be installed in premises (and vehicles), for providing context information, e.g., air temperature, luminance, humidity, human location and motion, etc. Then, to fill-in the growing gap between urban and rural areas and address the risks involved in elderly living on their own (about 1 in 3) by enabling professional carer groups to identify and react to health risks by monitoring at anytime and from anywhere (remotely) such real-time, activity and medical data of elderly living in rural and isolated areas, the project introduces an innovative, ontology-driven, open reference architecture and platform that will enable interoperability, seamless connectivity and sharing of content among different services.