Memorias de investigación
Research Project:
American Alzheimer Association (NIRG Program): Functional connectivity in elderly with subjective memory complaints

Research Areas
  • Cognitive neuroscience,
  • Insanity senile (alzheimer, parkinson),
  • Measurement of biological signals

In recent years, there is increasing interest in the early diagnosis of dementia as treatment is likely to have a better chance of success, before the severe biochemical and morphological alterations associated with the condition take place. Between 17% and 57% of elderly subjects complaint about their memory and some authors associate complaints with a higher risk for the development of dementia or with psycho-afective disorders. There is no clear anatomical or functional impairment in the brain of elders with subjective memory complaints (SMC), thus there is no a clear marker for pathology although it seems like they show higher acumulation of amyloid in their brains. Among elderly subjects with SMC some of them do not show cognitive impairment in traditional neuropsychological test. Thus it seems necessary a neurophysiological measure associated with cognitive symptoms and a biological marker reflecting the impairment on neuronal networks. In this proposal we raised the question of characterizing SMC from an functional (MEG) connectivity perspective (functional connectivity measures the statistical interdependencies between two brain electrophysiological signals (MEG/EEG) ) jointly with genetic, neuropsychological and clinical data. This is supported on the idea of understanding the process of dementia as a disconexion syndrome based on its hystopathological characteristics. Elders with SMC will be compared with normal elders (without SMC) and patients with Mild Cognitive Impairment in order to characterize all these preclinical stages. Finally, this proposal fits with one national (Spain) and one international (Spain-USA-UK-Japan-Finland) project-proposals leading by the mentor, and a series of projects funded by different institutions in the last 10 years.
Project type
Proyectos y convenios de financiación privada
American Alzheimer Association (NIRG program)
Entity Nationality
Entity size
Gran Empresa (>250)
Granting date
  • Director: Ricardo Bajo Breton UPM

Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB