Research Publications in journals:
Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes
Year:2012
Research Areas
- Artificial intelligence
Information
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Abstract
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| Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours. | |
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International
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JCR
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Title
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Plos One |
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ISBN
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1932-6203 |
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Impact factor JCR
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4,092 |
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Impact info
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Volume
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7 |
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Journal number
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8 |
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From page
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e42494 |
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To page
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e42494 |
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Month
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SIN MES |
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Ranking
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Open Access publication
Participants
- Autor: Marta Dueñas Molecular Oncology Unit, CIEMAT
- Autor: Mirentxu Santos Molecular Oncology Unit, CIEMAT
- Autor: Juan F. Aranda Molecular Oncology Unit, CIEMAT
- Autor: Maria Concepcion Bielza Lozoya UPM
- Autor: Ana B. Martínez-Cruz Molecular Oncology Unit, CIEMAT
- Autor: Corina Lorz Molecular Oncology Unit, CIEMAT
- Autor: Miquel Taron Catalan Institute of Oncology, Hospital Germans Trias i Pujol
- Autor: Eva M. Ciruelos Medical Oncology Department, Hospital Universitario 12 de Octubre
- Autor: José L. Rodríguez-Peralto Pathology Department, Hospital Universitario 12 de Octubre, and Instituto de Investigacion Hospital 12 de Octubre i+12
- Autor: Miguel Martín Hospital General Gregorio Marañón, Universidad Complutense, Madrid
- Autor: Pedro Maria Larrañaga Mugica UPM
- Autor: Jubrail Dahabreh Surgery Department, Athens Medical Center
- Autor: George P. Stathopoulos Oncology Department, Errikos Dunant Hospital, Athens
- Autor: Rafael Rosell Catalan Institute of Oncology, Hospital Germans Trias i Pujol
- Autor: Jesús M. Paramio Molecular Oncology Unit, CIEMAT
- Autor: Ramón García-Escudero Molecular Oncology Unit, CIEMAT
Research Group, Departaments and Institutes related
- Creador: Grupo de Investigación: COMPUTATIONAL INTELLIGENCE GROUP
- Departamento: Inteligencia Artificial