Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
Identifying the Semantics of Eligibility Criteria of Clinical Trials based on relevant Medical Ontologies
Año:2012
Áreas de investigación
  • Ciencias de la computación y tecnología informática
Datos
Descripción
An important objective of the INTEGRATE project1 is to build tools that support the efficient execution of post-genomic multi-centric clinical trials in breast cancer, which includes the automatic assessment of the eligibility of patients for available trials. The population suited to be enrolled in a trial is described by a set of free-text eligibility criteria that are both syntactically and semantically complex. At the same time, the assessment of the eligibility of a patient for a trial requires the (machineprocessable) understanding of the semantics of the eligibility criteria in order to further evaluate if the patient data available for example in the hospital EHR satisfies these criteria. This paper presents an analysis of the semantics of the clinical trial eligibility criteria based on relevant medical ontologies in the clinical research domain: SNOMED-CT, LOINC, MedDRA. We detect subsets of these widely-adopted ontologies that characterize the semantics of the eligibility criteria of trials in various clinical domains and compare these sets. Next, we evaluate the occurrence frequency of the concepts in the concrete case of breast cancer (which is our first application domain) in order to provide meaningful priorities for the task of binding/mapping these ontology concepts to the actual patient data. We further assess the effort required to extend our approach to new domains in terms of additional semantic mappings that need to be developed.
Internacional
Si
Nombre congreso
IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE2012)
Tipo de participación
960
Lugar del congreso
Larnaca, Cyprus
Revisores
Si
ISBN o ISSN
9781467343572
DOI
Fecha inicio congreso
11/11/2012
Fecha fin congreso
13/11/2012
Desde la página
413
Hasta la página
421
Título de las actas
Proceedings of a meeting held 11-13 November 2012
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Raul Alonso Calvo (UPM)
  • Autor: David Perez Del Rey (UPM)
  • Autor: A. Bucur
  • Autor: J. van Leeuwen
  • Autor: B. Claerhout
  • Autor: K. De Schepper
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Informática Biomédica (GIB)
  • Departamento: Inteligencia Artificial
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