Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
Spatio-temporal reconstruction of HIV-1B migration patterns in The Caribbean: a phylogenetic story
Año:2013
Áreas de investigación
  • Mecanismos moleculares de enfermedad,
  • Virus patógenos de animales
Datos
Descripción
The Caribbean is one of the regions with highest HIV-1 subtype B (HIV-1B) prevalence worldwide, with several countries reaching over 2% of the population infected. Despite of this high virus burden, little is known about the timing and the migration patterns of HIV-1B in this region. Migration is one of the major processes shaping the genetic structure and the evolutionary potential of virus populations. Thus, reconstructing the epidemiological network in The Caribbean may contribute to understand which factors determine the HIV-1B evolutionary dynamics. To address this subject, we have investigated the temporal and spatial dynamics of the HIV-1B epidemic in The Caribbean using 786 HIV-1B partial pol sequences from 13 Caribbean countries and a Bayesian Coalescent approach. Timing of HIV-1B introduction and virus evolutionary rates, the spatial genetic structure of the HIV-1B populations and the virus migration patterns were inferred. Results revealed that in The Caribbean HIV-1B could have been introduced in the 60s, but with most of the variability generated since the 80s. At odds with previous data suggesting that only Haiti was the origin of the epidemic in The Caribbean, our reconstruction indicated that the virus could have been also disseminated from Puerto Rico and Antigua. These two countries connected two distinguishable migration areas corresponding to the (mainly Spanish-colonized) Easter and (mainly British-colonized) Western islands, which indicates that virus migration patterns are determined by geographical barriers and by the movement of human populations among culturally related countries. The HIV-1B population was significantly structured according to the country of origin, and the genetic diversity in each country was associated with the virus prevalence, which suggests that populations evolve mainly through genetic drift. Thus, our work contributes to the understanding of HIV-1B evolution and dispersion pattern in the Americas, and its relationship with the geography of the area and the movements of human populations.
Internacional
No
Nombre congreso
XII Congreso Nacional de Virología
Tipo de participación
960
Lugar del congreso
Burgos
Revisores
Si
ISBN o ISSN
00-0000-00
DOI
Fecha inicio congreso
09/06/2013
Fecha fin congreso
12/06/2013
Desde la página
129
Hasta la página
130
Título de las actas
Virología. Publicación Oficial de la Sociedad española de Virología
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Jesus Israel Pagan Muñoz (UPM)
  • Autor: África Holguin (Hospital Ramón y Cajal, Madrid)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Patología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)