Memorias de investigación
Artículos en revistas:
Network-based biomarkers in Alzheimer?s disease: review and future directions
Año:2013
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Datos
Descripción
By 2050 it is estimated that the number of worldwide Alzheimer?s disease (AD) patients will quadruple from the current number of 36 million people. To date, no single test, prior to postmortem examination, can confirm that a person suffers from AD. Therefore, there is a strong need for accurate and sensitive tools for the early diagnoses of AD. The complex etiology and multiple pathogenesis of AD call for a system-level understanding of the currently available biomarkers and the study of new biomarkers via network-based modeling of heterogeneous data types. In this review, we summarize recent research on the study of AD as a connectivity syndrome. We argue that a network-based approach in biomarker discovery will provide key insights to fully understand the network degeneration hypothesis (disease starts in specific network areas and progressively spreads to connected areas of the initial loci-networks) with a potential impact for early diagnosis and disease-modifying treatments. We introduce a new framework for the quantitative study of biomarkers that can help shorten the transition between academic research and clinical diagnosis in AD.
Internacional
Si
JCR del ISI
Si
Título de la revista
Front. Aging Neurosci.
ISSN
1663-4365
Factor de impacto JCR
5,2
Información de impacto
Volumen
12
DOI
doi: 10.3389/fnagi.2014.00012
Número de revista
6
Desde la página
1
Hasta la página
9
Mes
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Participantes
  • Autor: Jaime Gómez Ramírez UPM
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Laboratorio de Sistemas Autónomos
  • Departamento: Automática, Ingeniería Electrónica e Informática Industrial