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Memorias de investigación
Artículos en revistas:
Role of Art v 3 in pollinosis of patients allergic to Pru p 3.
Año:2014
Áreas de investigación
  • Mecanismos moleculares de enfermedad
Datos
Descripción
Background: Food allergy caused by lipid transfer protein (LTP) from peach (Pru p 3) is frequently associated with sensitization to mugwort LTP (Art v 3). Although in vitro cross-reactivity is already well known, it has yet to be elucidated whether a pollen LTP can induce rhinitis. Objective: The aim of this study was to investigate whether mugwort LTP could elicit respiratory symptoms and whether a primary food LTP allergy could lead to a respiratory allergy. Methods: Patients with confirmed Pru p 3 allergy and control subjects were selected. Immediate responses to nasal allergen provocation tests (NAPTs) with Art v 3, Pru p 3, and mugwort were assessed by using the visual analog scale score, total nasal symptom score, and acoustic rhinometry. Tryptase and cysteinyl leukotriene (cysLT) levels were measured in nasal lavage fluid. Immunoblotting, ELISAs, and ELISA inhibition assays were also performed. Results: Fifteen patients and 9 control subjects were selected. NAPT results with Art v 3 and Pru p 3 showed significant changes in acoustic rhinometry, visual analog scale scores, total nasal symptom scores, and cysLT levels (P < .001). Tryptase levels were only increased in NAPTs with Pru p 3. NAPTs with mugwort were used in those patients who were only sensitized to Art v 3, with similar results (P < .05). No significant changes were detected in control subjects. Conclusion: The results demonstrated that a pollen LTP can elicit rhinitis in sensitized patients. Findings also suggest that a primary sensitization to Pru p 3 can lead to a respiratory allergy through cross-reactivity.
Internacional
Si
JCR del ISI
Si
Título de la revista
The Journal of Allergy And Clinical Immunology
ISSN
0091-6749
Factor de impacto JCR
12,047
Información de impacto
Volumen
133
DOI
Número de revista
Desde la página
1018
Hasta la página
1025
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: J Sánchez-López (Hospital Clinic Barcelona)
  • Autor: Leticia Tordesillas (UPM)
  • Autor: Mariona Pascal (Hospital Clinic Barcelona)
  • : R Muñoz-Cano
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: M Rueda
  • Autor: R Vilella
  • Autor: A Valera
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: C Picado
  • Autor: J Bartra
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
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