Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Molecular Dynamics of Major Allergens from Alternaria, Birch Pollen and Peach
Año:2014
Áreas de investigación
  • Biología molecular, celular y genética
Datos
Descripción
Abstract: In the search for factors that make a protein allergenic (an issue that remains so far elusive) some common features of allergens such as small size, high stability and lipid binding are recognized in spite of their structural diversity. Other relevant but still poorly understood feature is their capability to form homodimers. We investigated by means of Molecular Dynamics (MD) calculations the stability in solution of several dimers of three major allergens from Alternaria mold, birch pollen, and peach fruit known to play essential roles in allergic disease. By running 20 ns MD simulations we found essential properties on solution that provide information of interest on their dimerization, stability of their epitopes and dynamical features of ligand binding cavities. Our results show that three essential allergen proteins display a distinct behavior on their trends to form homodimers in solution.
Internacional
Si
JCR del ISI
Si
Título de la revista
Molecular Informatics
ISSN
1868-1743
Factor de impacto JCR
2,013
Información de impacto
Volumen
DOI
Número de revista
Desde la página
682
Hasta la página
694
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Cristina Gomez Casado (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Sistemas y Recursos Naturales
  • Departamento: Biotecnología - Biología Vegetal
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