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Abstract
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| Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive impairment, and a variety of neuropathological changes, which are not homogenous between different brain regions within a given patient or between patients. The availability of techniques to explore the brain provides neuroscientists a wealth of data that is difficult to analyze, as a result of both its volume and its complexity. In order to overcome this problem, we propose to apply a new interactive exploratory data analysis tool, MorExAn (Morphology Exploratory Analyzer), which has been specifically designed to facilitate the study of complex neuroscientific data. In the present study, we used brain tissue from 10 patients with AD (age range 76 - 90 years old). We included quantitative stereological data of several histological features (e.g., neuron and plaques density) obtained from different hippocampal regions, as well as neuropsychological data and common clinical variables. Simultaneous analysis of data using MorExAn allows researchers to immediately detect possible differences between regions and relationships between different types of data. Thus, MorExAn provide us the possibility to relate histopathological data with neuropsychological and clinical variables. The aid of this interactive visualization tool brings us the possibility to find unexpected conclusions beyond the insight provided by simple statistics analysis, as well as to improve neuroscientists? productivity. | |
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International
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Si |
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Congress
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Conference Abstract: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop) |
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960 |
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Place
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Barcelona, Spain |
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Reviewers
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Si |
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ISBN/ISSN
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1662-5137 |
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10.3389/conf.fnsys.2015.06.00002 |
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Start Date
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29/04/2015 |
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End Date
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30/04/2015 |
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From page
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1 |
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To page
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1 |
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A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing |