Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
Changes in anatomical and functional connectivity related to lower hippocampal volume
Año:2014
Áreas de investigación
  • Procesamiento de imágenes
Datos
Descripción
Anatomical 3D T1 weighted images have been widely used to assess the volume of subcortical structures. It has been demonstrated that volume loss of hippocampi, entorhinal cortex and amygdala are early biomarkers for the diagnosis of cognitive impairments and AD1. In this work, we investigate AD biomarkers based on brain connectivity. SC-FC differences have been reported between controls and patients at risk for AD2. We will try to anticipate to MCI or AD diagnoses by differentiating in a sample of healthy subjects, i.e. with no cognitive impairment, other than related to ageing, using as criterion of separation the normalized hippocampal volume (NHV). The sample is formed by volunteers in the Valleca?s Initiative, a longitudinal study evaluating normal ageing in a cohort of more than 600 healthy elder people (70-85 years). The prevalence of AD in people older than 65 years is 13%3 suggesting that a certain number of those subjects will develop AD in the next years. The subjects with lower NHV are more prone to have AD than subjects with higher NHV. Thus they are more likely to manifest connectivity patterns that can be considered as AD biomarkers.
Internacional
Si
Nombre congreso
International Society for Magnetic Resonance in Medicine
Tipo de participación
960
Lugar del congreso
Milan, Italia
Revisores
Si
ISBN o ISSN
2051-7505
DOI
Fecha inicio congreso
09/05/2014
Fecha fin congreso
16/05/2014
Desde la página
6890
Hasta la página
0
Título de las actas
Joint ISMRM-ESMRMB Milano 2014
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Jose Angel Pineda Pardo (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
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