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Memorias de investigación
Artículos en revistas:
Parenclitic networks: uncovering new functions in biological data
Año:2014
Áreas de investigación
  • Biología funcional,
  • Bioinformática
Datos
Descripción
We introduce a novel method to represent time independent, scalar data sets as complex networks. We apply our method to investigate gene expression in the response to osmotic stress of Arabidopsis thaliana. In the proposed network representation, the most important genes for the plant response turn out to be the nodes with highest centrality in appropriately reconstructed networks. We also performed a target experiment, in which the predicted genes were artificially induced one by one, and the growth of the corresponding phenotypes compared to that of the wild-type. The joint application of the network reconstruction method and of the in vivo experiments allowed identifying 15 previously unknown key genes, and provided models of their mutual relationships. This novel representation extends the use of graph theory to data sets hitherto considered outside of the realm of its application, vastly simplifying the characterization of their underlying structure.
Internacional
Si
JCR del ISI
Si
Título de la revista
Scientific Reports
ISSN
2045-2322
Factor de impacto JCR
5,578
Información de impacto
Datos JCR del año 2014
Volumen
4
DOI
10.1038/srep05112
Número de revista
5112
Desde la página
1
Hasta la página
6
Mes
MAYO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Massimiliano Zanin Zanin (UPM)
  • Autor: Joaquin Medina Alcazar (UPM)
  • Autor: Jesus Vicente Carbajosa (UPM)
  • Autor: Dennys Marcela Gomez Paez (UPM)
  • Autor: David Papo . (UPM)
  • Autor: Pedro Sousa (Faculdade de Ciências e Tecnologia, Departamento de Engenharia Electrotécnica, Universidade Nova de Lisboa)
  • Autor: Ernestina Menasalvas Ruiz (UPM)
  • Autor: Stefano Boccaletti (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Lenguajes y Sistemas Informáticos e Ingeniería de Software
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