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Abstract
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| A constant challenge in experimental stroke is the use of appropriate tests to identify signs of functional recovery and possible adverse effects linked to a particular therapy. In this study we used a long-term longitudinal approach to examine the functional brain changes associated with cortical infarction in a mouse model induced by permanent ligation of the middle cerebral artery. Somatosensory cortical function was evaluated with fault-foot and forelimb asymmetry tests in combination with evoked potentials. The stroke mice exhibited both long-term deficits in the functional tests and impaired responses in the infarcted and intact hemispheres after contralateral and ipsilateral forepaw stimulation. In the infarcted hemisphere reductions in evoked responses were detected after contralateral and ipsilateral stimulation. In the intact hemisphere, and similar to cortical stroke patients, a gradual hyperexcitability was observed after contralateral stimulation but no parallel evidence of a response was detected after ipsilateral stimulation. Our results suggest the existence of profound and persistent changes in the somatosensory cortex in this specific mouse cortical stroke model. Additionally, evoked potentials constitute a feasible and excellent tool for evaluating the fitness of the somatosensory cortex in relation to functional recovery after preclinical therapeutic intervention | |
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International
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Si |
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Congress
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FUNDACION BBVA- workshop recent advances in bioinformatics and neuroscience |
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970 |
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Place
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MADRID, SPAIN |
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Reviewers
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Si |
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ISBN/ISSN
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CDP08UPM |
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Start Date
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09/06/2015 |
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End Date
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09/06/2015 |
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From page
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26 |
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To page
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26 |
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Abstract_book BBVA |