Memorias de investigación
Artículos en revistas:
Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud,
  • Biología molecular, celular y genética,
  • Ciencias biológicas,
  • Biología humana,
  • Biología molecular,
  • Ingeniería biológica,
  • Biología vegetal, animal y ecología,
  • Ciencias de la nutrición
Datos
Descripción
Owners and their domestic animals via skin shedding and secretions, mutually exchange microbiomes, potential pathogens and innate immune molecules. Among the latter especially lipocalins are multifaceted: they may have an immunomodulatory function and, furthermore, they represent one of the most important animal allergen families. The amino acid identities, as well as their structures by superposition modeling were compared among human lipocalins, hLCN1 and hLCN2, and most important animal lipocalin allergens, such as Can f 1, Can f 2 and Can f 4 from dog, Fel d 4 from cats, Bos d 5 from cow's milk, Equ c 1 from horses, and Mus m 1 from mice, all of them representing major allergens. The ?-barrel fold with a central molecular pocket is similar among human and animal lipocalins. Thereby, lipocalins are able to transport a variety of biological ligands in their highly conserved calyx-like cavity, among them siderophores with the strongest known capability to complex iron (Fe(3+) ). Levels of human lipocalins are elevated in nonallergic inflammation and cancer, associated with innate immunoregulatory functions that critically depend on ligand load. Accordingly, deficient loading of lipocalin allergens establishes their capacity to induce Th2 hypersensitivity. Our similarity analysis of human and mammalian lipocalins highlights their function in innate immunity and allergy.
Internacional
Si
JCR del ISI
Si
Título de la revista
Allergy
ISSN
0105-4538
Factor de impacto JCR
6,028
Información de impacto
Volumen
71
DOI
Número de revista
Desde la página
286
Hasta la página
294
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: E Jensen-Jarolim The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
  • Autor: Luis Fernandez Pacios UPM
  • Autor: R Bianchini The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
  • Autor: G Hofsletter The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
  • Autor: F Roth-Walter The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Sistemas y Recursos Naturales