Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Wheat allergy in celiac children
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud,
  • Biología molecular, celular y genética,
  • Ciencias biológicas,
  • Biología vegetal, animal y ecología,
  • Ciencias biológicas,
  • Ciencias ambientales
Datos
Descripción
Gluten is the main structural protein complex of wheat with equivalent toxic proteins found in other cereals (rye, barley, and oats) which are responsible for different immunologic responses with different clinical expressions of disease. The spectrum of gluten-related disorders has been classified according to pathogenic, clinical, and epidemiological differences in three main forms: (i) wheat allergy (WA), an IgE-mediated disease; (ii) autoimmune disease, including celiac disease (CD), dermatitis herpetiformis, and gluten ataxia; and (iii) possibly immune-mediated, gluten sensitivity [1]. WA is an immunologic Th2 response with typical manifestations which can vary from dermatological, respiratory, and/or intestinal to anaphylactic reactions. In contrast, CD is an autoimmune disorder, a gliadin-specific T-cell response which is enhanced by the action of intestinal tissue transglutaminase (tTG), with a wide clinical spectrum including symptomatic cases with either intestinal (e.g., chronic diarrhea, weight loss) or extraintestinal features (e.g., anemia, osteoporosis, neurologic disturbances) and silent forms that are occasionally discovered as a result of serological screening [1]. We studied wheat allergy in two children with early diagnosis of CD, who developed immediate allergic symptoms after eating small amounts of wheat flour.
Internacional
Si
JCR del ISI
Si
Título de la revista
Pediatric Allergy And Immunology
ISSN
0905-6157
Factor de impacto JCR
3,859
Información de impacto
Volumen
27
DOI
Número de revista
Desde la página
92
Hasta la página
106
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: MF Martín-Muñoz (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. fmartinmz@gmail.com.)
  • Autor: D Rivero (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.)
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: I Polanco (Pediatric Department, Hospital La Paz Instituto de Investigación (idiPaz), Madrid, Spain.)
  • Autor: S Quirce (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
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