Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Bronchial Challenge With Tri a 14 as an Alternative Diagnostic Test for Baker?s Asthma
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud,
  • Tecnología de alimentos,
  • Biología molecular, celular y genética,
  • Ciencias biológicas,
  • Biología vegetal, animal y ecología,
  • Ciencias biológicas,
  • Ciencias ambientales
Datos
Descripción
BACKGROUND: Baker's asthma (BA) is the most prevalent occupational respiratory disease in developed countries. It is caused by inhalation of wheat dust in the working environment and affects 1%-10% of workers in the baking industry. Diagnosis of BA is based on bronchial challenge with wheat, a technique that carries a high risk for patients. The wheat lipid transfer protein Tri a 14 is a major allergen in BA. OBJECTIVE: The aim of our study was to characterize Tri a 14 as a marker of BA in order to prevent patients from having to undergo bronchial challenge with wheat. METHODS: The study population comprised 55 patients selected at the Rio Hortega Hospital, Valladolid, Spain. Patients with BA were diagnosed using a skin prick test (SPT) with wheat and Tri a 14 and bronchial challenge test (BCT) with wheat. Patients with food allergy had a clear clinical history of allergy to peach confirmed by positive SPT to peach extract and Pru p 3. RESULTS: All patients in the BA group had a positive SPT result with wheat (100%), and most had positive results with Tri a 14 (95%). A positive BCT result with Tri a 14 was also observed in 22 of 27 of the patients with BA (82%). The response to Tri a 14 was specifically associated with BA. CONCLUSION: Tri a 14 is a good marker of BA and can be used in SPT and BCT as an alternative diagnostic method, thus avoiding bronchial challenge with wheat and reducing the risk associated with this technique.
Internacional
Si
JCR del ISI
Si
Título de la revista
Journal of Investigational Allergology And Clinical Immunology
ISSN
1018-9068
Factor de impacto JCR
2,642
Información de impacto
Volumen
25
DOI
Número de revista
Desde la página
352
Hasta la página
357
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: A Armentia (Allergy section, University Hospital Rio Hortega, Valladolid, Spain)
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Nuria Cubells Baeza (UPM)
  • Autor: C Gómez Casado (Centre for Plant Biotechnology and Genomics (UPM-INIA), Madrid, Spain)
  • Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
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