Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Identification of Novel Components of the Unfolded Protein Response in Arabidopsis
Año:2016
Áreas de investigación
  • Biología funcional,
  • Biotecnología de plantas
Datos
Descripción
Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.
Internacional
Si
JCR del ISI
Si
Título de la revista
Frontiers in Plant Science
ISSN
1664-462X
Factor de impacto JCR
3,948
Información de impacto
Volumen
7
DOI
10.3389/fpls.2016.00650
Número de revista
00650
Desde la página
1
Hasta la página
12
Mes
MAYO
Ranking
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Participantes
  • Autor: Mohammad Amir Hossain . (UPM)
  • Autor: Carlos Henríquez-Valencia (Centro de Biotecnología Vegetal, FONDAP Center for Genome Regulation, Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago de Chile)
  • Autor: Dennys Marcela Gomez Paez (UPM)
  • Autor: Joaquin Medina Alcazar (UPM)
  • Autor: Ariel Orellana (Centro de Biotecnología Vegetal, FONDAP Center for Genome Regulation, Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago, Chile)
  • Autor: Jesus Vicente Carbajosa (UPM)
  • Autor: Jan Zouhar (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
  • Departamento: Biotecnología - Biología Vegetal
S2i 2023 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
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