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Memorias de investigación
Artículos en revistas:
Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Datos
Descripción
We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two strains of rats. Strain-specific differences were observed prior to cocaine self-administration: LEW rats had significantly larger dendritic diameters but lower spine density than the F344 strain. After cocaine self-administration, proximal dendritic volume, dendritic surface area and spine density were increased in LEW rats, where a higher percentage of larger spines were also observed. In addition, we found a strong positive correlation between dendritic volume and spine morphology, and a moderate correlation between dendritic volume and spine density in cocaine self-administered LEW rats, an effect that was not evident in any other condition. By contrast, after cocaine self-administration, F334 rats showed decreased spine head volumes. Our findings suggest that genetic differences could play a key role in the structural plasticity induced by cocaine in CA1 pyramidal neurons. These cocaine-induced alterations could be related to differences in the memory processing of drug reward cues that could potentially explain differential individual vulnerability to cocaine addiction.
Internacional
Si
JCR del ISI
Si
Título de la revista
Addict Biol
ISSN
1355-6215
Factor de impacto JCR
5,359
Información de impacto
Volumen
DOI
0.1111/adb.12294
Número de revista
Desde la página
1
Hasta la página
15
Mes
SEPTIEMBRE
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Participantes
  • Autor: Santiago M. Coria (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Abraham Selvas (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Asta Kastanauskaite . (UPM)
  • Autor: Isabel Fernaud Espinosa (UPM)
  • Autor: Javier De Felipe Oroquieta (UPM)
  • Autor: Emilio Ambrosio (Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Miguel Miguens Vazquez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos
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