Artículos en revistas:
Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Año:2015
Áreas de investigación
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Ciencias naturales y ciencias de la salud
Datos
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Descripción
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| We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two strains of rats. Strain-specific differences were observed prior to cocaine self-administration: LEW rats had significantly larger dendritic diameters but lower spine density than the F344 strain. After cocaine self-administration, proximal dendritic volume, dendritic surface area and spine density were increased in LEW rats, where a higher percentage of larger spines were also observed. In addition, we found a strong positive correlation between dendritic volume and spine morphology, and a moderate correlation between dendritic volume and spine density in cocaine self-administered LEW rats, an effect that was not evident in any other condition. By contrast, after cocaine self-administration, F334 rats showed decreased spine head volumes. Our findings suggest that genetic differences could play a key role in the structural plasticity induced by cocaine in CA1 pyramidal neurons. These cocaine-induced alterations could be related to differences in the memory processing of drug reward cues that could potentially explain differential individual vulnerability to cocaine addiction. | |
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Internacional
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Si |
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JCR del ISI
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Si |
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Título de la revista
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Addict Biol |
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ISSN
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1355-6215 |
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Factor de impacto JCR
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5,359 |
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Información de impacto
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Volumen
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DOI
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0.1111/adb.12294 |
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Número de revista
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1 |
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15 |
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Mes
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SEPTIEMBRE |
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Ranking
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Participantes
- Autor: Santiago M. Coria (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
- Autor: Abraham Selvas (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
- Autor: Asta Kastanauskaite . (UPM)
- Autor: Isabel Fernaud Espinosa (UPM)
- Autor: Javier De Felipe Oroquieta (UPM)
- Autor: Emilio Ambrosio (Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
- Autor: Miguel Miguens Vazquez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
- Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
- Departamento: Arquitectura y Tecnología de Sistemas Informáticos
S2i 2023 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)