Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
Nanomedicine Application of Alternative Therapy Cancer Treatment in Animal Models with High-Grade Gliomas CT-2A
Áreas de investigación
  • Tecnología electrónica y de las comunicaciones
Cancer is one of the leading causes of death worldwide. It is expected that annual cases of cancer will increase from 14 million in 2012 to 22 million in the next two decades according to the World Health Organization [1]. On the other hand, the estimates of the Spanish Society of Medical Oncology for 2015 point out 227076 new cases only in Spain [2]. Tumors of glial cells, anaplastic astrocytoma and glioblastoma account for approximately 38% of primary brain tumors [3]. At present, despite the development of existing treatments such as chemotherapy, radiation therapy and neurosurgery these tumors tend to breed again, leading to a high mortality rate. The Center for Biomedical Technology (CTB) of the Technical University of Madrid (UPM) in cooperation with the Cajal Institute of the Spanish Council for Scientific Research (CSIC), research has been done with an application of nanomedicine using therapy through optical hyperthermia, taking as the starting point the results of in vitro experimentation with prior glioblastoma cells, using gold nanorods with laser at a wavelength of 808 nanometers, a wavelength in which tissue penetration is more efficient [4,5]. For this, it was used a syngeneic mouse model of glioblastoma by injecting of CT-2A astrocytoma cells into the caudate-putamen of C57BL/6 mice, as previously reported [6]. Five mice were used and distributed as follows: Control nanoparticles (NPs), NPs + laser therapy 15 minutes, plus 25 minutes NPs laser therapy, laser therapy and tumor control without NPs. The results of these experiments, in which the mice population was not large enough from a statistical point of view, showed comparing the individual control NPs versus animal therapy NPs + 15 laser minutes groups, a reduction of tumor growth (volume) of 15.99% which implies a reduction in the volume of 82,97 mm3. The observations of tumor volumes were made using Nuclear Magnetic Resonance. Future work will seek to optimize the intracranial stereotactic surgical method implemented in these experiments with mice as well as to increase the number of individuals to produce statistics that effectively validate this application.
Nombre congreso
NANOBIOAPP2015: Latest Advances on Nanomaterials for Biomedical Applications
Tipo de participación
Lugar del congreso
Barcelona, España
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Título de las actas
Esta actividad pertenece a memorias de investigación
  • Autor: Oscar Casanova Carvajal (UPM)
  • Autor: Ana Lorena Urbano Bojorge (UPM)
  • Autor: Patricia Galán
  • Autor: Cristina Sanchez Lopez de Pablo (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: Ricardo Murillo
  • Autor: Jose Javier Serrano Olmedo (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2022 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)