Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Wiring economy of pyramidal cells in the juvenile rat somatosensory cortex
Año:2016
Áreas de investigación
  • Inteligencia artificial
Datos
Descripción
Ever since Cajal hypothesized that the structure of neurons is designed in such a way as to save space, time and matter, numerous researchers have analyzed wiring properties at different scales of brain organization. Here we test the hypothesis that individual pyramidal cells, the most abundant type of neuron in the cerebral cortex, optimize brain connectivity in terms of wiring length. In this study, we analyze the neuronal wiring of complete basal arborizations of pyramidal neurons in layer II, III, IV, Va, Vb and VI of the hindlimb somatosensory cortical region of postnatal day 14 rats. For each cell, we search for the optimal basal arborization and compare its length with the length of the real dendritic structure. Here the optimal arborization is defined as the arborization that has the shortest total wiring length provided that all neuron bifurcations are respected and the extent of the dendritic arborizations remain unchanged. We use graph theory and evolutionary computation techniques to search for the minimal wiring arborizations. Despite morphological differences between pyramidal neurons located in different cortical layers, we found that the neuronal wiring is near-optimal in all cases (the biggest difference between the shortest synthetic wiring found for a dendritic arborization and the length of its real wiring was less than 5%). We found, however, that the real neuronal wiring was significantly closer to the best solution found in layers II, III and IV. Our studies show that the wiring economy of cortical neurons is related not to the type of neurons or their morphological complexities but to general wiring economy principles.
Internacional
Si
JCR del ISI
Si
Título de la revista
Plos One
ISSN
1932-6203
Factor de impacto JCR
3,057
Información de impacto
Datos JCR del año 2015
Volumen
11
DOI
10.1371/journal.pone.0165915
Número de revista
Desde la página
1
Hasta la página
10
Mes
SIN MES
Ranking
Ranking: 11/63 (Quartile 1). Category: Multidisciplinary sciences
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Laura Anton Sanchez (UPM)
  • Autor: Maria Concepcion Bielza Lozoya (UPM)
  • Autor: Pedro Maria Larrañaga Mugica (UPM)
  • Autor: Javier De Felipe Oroquieta (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Computational Intelligence Group
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Inteligencia Artificial
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)