Descripción
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Mammals including humans use highly specific pathways for tissue differentiation. One such pathway is operative in reticulocytes and involves the programmed destruction of the cell?s organellar complement by 15-lipoxygenase (15-LOX), which oxygenates polyunsaturated membrane fatty acids and provokes organelle leakage. As we report here, plants make use of a similar LOX pathway to degrade their chloroplasts during leaf senescence. The enzyme involved is a 13-LOX with unique positional specificity and molecular terms. Because 15-LOX and 13-LOX pathway products likewise operate in biological defense, a mechanism of cross-kingdom conservation of pathway regulation and function was uncovered for multicellular eukaryotes. | |
Internacional
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Si |
JCR del ISI
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Si |
Título de la revista
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Proceedings of the National Academy of Sciences of the United States of America |
ISSN
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0027-8424 |
Factor de impacto JCR
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9,809 |
Información de impacto
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Datos JCR del año 2013 |
Volumen
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113 |
DOI
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10.1073/pnas.1525747113 |
Número de revista
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12 |
Desde la página
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3383 |
Hasta la página
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3388 |
Mes
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MARZO |
Ranking
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