Memorias de investigación
Artículos en revistas:
'Composite scaffold for osteochandral repair obteined by combination od additive manufacturing, particle leaching and hMSC-CM functionalization'
Año:2016
Áreas de investigación
  • Ingenieria mecanica,
  • Herramientas
Datos
Descripción
Articular repair is a relevant and challenging area for the emerging fields of tissue engineering and biofabrication. The need of significant gradients of properties, for the promotion of osteochondral repair, has led to the development of several families of composite biomaterials and scaffolds, using different effective approaches, although a perfect solution has not yet been found. In this study we present the design, modeling, rapid manufacturing and in vitro testing of a composite scaffold aimed at osteochondral repair. The presented composite scaffold stands out for having a functional gradient of density and stiffness in the bony phase, obtained in titanium by means of computer-aided design combined with additive manufacture using selective laser sintering. The chondral phase is obtained by sugar leaching, using a PDMS matrix and sugar as porogen, and is joined to the bony phase during the polymerization of PDMS, therefore avoiding the use of supporting adhesives or additional intermediate layers. The mechanical performance of the construct is biomimetic and the stiffness values of the bony and chondral phases can be tuned to the desired applications, by means of controlled modifications of different parameters. A humanmesenchymal stemcell (h-MSC) conditionedmedium(CM) is used for improving scaffold response. Cell culture results provide relevant information regarding the viability of the composite scaffolds used.
Internacional
Si
JCR del ISI
No
Título de la revista
Materials Science and Engineering C: Materials in Biology and Medicine
ISSN
0928-4931
Factor de impacto JCR
Información de impacto
Volumen
DOI
Número de revista
Desde la página
217
Hasta la página
218
Mes
SIN MES
Ranking
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Participantes
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: GI-IM: Grupo de Investigación en Ingeniería de Máquinas
  • Departamento: Ingeniería Mecánica