Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Applicability of epithelial models in protein permeability/transport studies and food allergy
Año:2016
Áreas de investigación
  • Biología molecular, celular y genética
Datos
Descripción
Measurement of protein transport across the intestinal barrier might be a relevant approach in allergenicity risk assessment. Traditionally, studies on protein transport, were performed using stable cell lines cultured as a monolayer. One of the major advantages of these models is their relatively low price and easy handling. However, monolayers lack a physiologically relevant environment (presence of other cell-types and a mucus layer), which may have an effect on transport characteristics and thus correct prediction of protein allergenicity. This paper summarizes the most widely used epithelial models and discusses their benefits and limitations for measuring protein transport and allergic sensitization to food
Internacional
No
JCR del ISI
No
Título de la revista
Drug Discovery Today. Disease Models
ISSN
1740-6757
Factor de impacto JCR
Información de impacto
Volumen
DOI
10.1016/j.ddmod.2016.08.002
Número de revista
Desde la página
1
Hasta la página
9
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Nuria Cubells Baeza (UPM)
  • Autor: K.C.M Verhoeckx (TNO)
  • Autor: C Larre (INRA)
  • Autor: S Denery-Papini (INRA,)
  • Autor: M. Gavrovic-Jankulovic (University of Belgrade)
  • Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Biotecnología - Biología Vegetal
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