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Descripción
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| The lipid transfer protein Pru p 3 is one of the most common plant food allergens among adults in Southern Europe with a prevalence that has been increasing particularly in children. LTP allergy is frequently life-long and is also one of the causes of anaphylactic reactions that are potentially life-threatening. However, the origin of its immunological activity is unknown.The nature of the lipid-ligand of Pru p 3 has recently been identified as a derivative of the alkaloid camptothecin linked to a phytosphingosine tail. Taking into account that lipids can induce immune responses, in this work we have evaluated the immunogenic activity of this lipid-ligand using a range of in vitro models (moDC, PBMCs, THP1 and epithelial cells as Caco2), and a mouse model of anaphylaxis to peach. We have determined that the lipid-ligand of Pru p 3 could act as an adjuvant with the ability to modulate the immune system presumably toward a Th2 response characteristic of allergy as it has been demonstrated in a mouse model of anaphylaxis. Moreover, the lipid-ligand of Pru p 3 co-localized to CD1d in epithelial cells (Caco2) and interacted to Cd1d tetramers to activate iNKT of the immune system. | |
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Internacional
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JCR del ISI
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Título de la revista
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Clinical And Experimental Allergy |
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ISSN
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0954-7894 |
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Factor de impacto JCR
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5,587 |
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Información de impacto
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Datos JCR del año 2015 |
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Volumen
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DOI
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10.1111/cea.12962 |
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Número de revista
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1 |
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Hasta la página
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10 |
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Mes
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