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Memorias de investigación
Artículos en revistas:
Mechanisms underlying induction of allergic sensitization by Pru p 3
Año:2017
Áreas de investigación
  • Biología molecular, celular y genética
Datos
Descripción
The lipid transfer protein Pru p 3 is one of the most common plant food allergens among adults in Southern Europe with a prevalence that has been increasing particularly in children. LTP allergy is frequently life-long and is also one of the causes of anaphylactic reactions that are potentially life-threatening. However, the origin of its immunological activity is unknown.The nature of the lipid-ligand of Pru p 3 has recently been identified as a derivative of the alkaloid camptothecin linked to a phytosphingosine tail. Taking into account that lipids can induce immune responses, in this work we have evaluated the immunogenic activity of this lipid-ligand using a range of in vitro models (moDC, PBMCs, THP1 and epithelial cells as Caco2), and a mouse model of anaphylaxis to peach. We have determined that the lipid-ligand of Pru p 3 could act as an adjuvant with the ability to modulate the immune system presumably toward a Th2 response characteristic of allergy as it has been demonstrated in a mouse model of anaphylaxis. Moreover, the lipid-ligand of Pru p 3 co-localized to CD1d in epithelial cells (Caco2) and interacted to Cd1d tetramers to activate iNKT of the immune system.
Internacional
Si
JCR del ISI
Si
Título de la revista
Clinical And Experimental Allergy
ISSN
0954-7894
Factor de impacto JCR
5,587
Información de impacto
Datos JCR del año 2015
Volumen
DOI
10.1111/cea.12962
Número de revista
Desde la página
1
Hasta la página
10
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Leticia Tordesillas (Icahn School of Medicine at Mount Sinai)
  • Autor: Nuria Cubells Baeza (UPM)
  • Autor: Cristina Gómez-Casado (CEU San Pablo University)
  • Autor: Vanesa Esteban (Fundación Jimenez Díaz)
  • Autor: Weronika Barcik (swiss institute allergy asthma research (SIAF))
  • Autor: Liam O'Mahony (swiss institute allergy asthma research (SIAF))
  • Autor: Maria del Carmen Ramirez Castillejo (UPM)
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Biotecnología - Biología Vegetal
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