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Descripción
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| Multiple levels of regulation tightly control and coordinate eukaryotic gene expression. Studies on yeast and filamentous fungi have revealed that some cellular processes that regulate gene expression are not present, or have evolved in a different way, in these organisms compared to other eukaryotes. Consequently, regardless of the overall events governing the flow of genetic information being highly conserved - i.e., transcription, splicing and polyadenylation - there is a large diversity-space within which individual proteins and regulatory mechanisms may fine-tune eukaryotic gene expression. We characterized the evolutionary history of the major protein complexes, and their constituent proteins, for complexes that participate in fungal mRNA metabolism. The protein repertoire included more than 300 proteins spanning the functions of transcription, polyadenylation and splicing, and spanning the major branches of the fungal kingdom. Orthologues were identified using EnseEMBL?s (Kersey et al., 2016) and OMA?s (Altenhoff A et al., 2015) classification. Interestingly, we discovered variable conservation patterns that corresponded with the phylogenetic classification of fungi. In some cases, protein domain architecture indicated a species-specific conservation of certain domains. Differences were also found at the genome and transcriptome levels regarding intron/exon structure, UTR architecture, polyadenylation site selection, and protein-binding motifs. Our results suggest that the knowledge of these processes acquired from model species such as yeasts and human will not be sufficient to represent the diversity of these functionalities within the fungal kingdom. | |
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Internacional
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Si |
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Nombre congreso
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Workshop New Frontiers in Plant Biology |
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Tipo de participación
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970 |
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Lugar del congreso
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Centro de Biotecnología y Genómica de Plantas |
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Revisores
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Si |
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ISBN o ISSN
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0000-0000 |
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DOI
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Fecha inicio congreso
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15/06/2016 |
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Fecha fin congreso
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17/06/2016 |
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Desde la página
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23 |
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Hasta la página
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23 |
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Título de las actas
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Evolutionary patterns of protein complexes involved in mRNA metabolism in the fungal kingdom |