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Memorias de investigación
Ponencias en congresos:
Deciphering the molecular mechanism underlying the broad-spectrum disease resistance regulated by ERECTA-YODA immune pathway
Año:2016
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Datos
Descripción
YODA (YDA) is a MAPK kinase kinase (MAP3K) that functions downstream the Receptor Like Kinase (RLK) ERECTA (ER). YDA-ER pathway control Arabidopsis immune responses, but also stomatal patterning and other plant developmental-associated processes. Remarkably, plants expressing a constitutively active form of YDA (CA-YDA) show broad-spectrum disease resistance to different type of pathogens, including fungi, oomycetes, and bacteria. CA-YDA-mediated resistance is independent of defensive pathways regulated by salicylic acid, jasmonic acid or ethylene, and of previously characterised canonical immune pathways activated by Microbe-Associated Molecular Patterns (MAMPs). Comparative transcriptomic analyses of mock and fungal-inoculated wild-type and CA-YDA plants revealed that CA-YDA plants constitutively express a set of defense-associated genes, which encoded uncharacterised RLKs and putative extracellular peptides (ePEPs). We selected Arabidopsis mutants impaired in the expression of these ePEPs and tested their contribution to resistance against the fungal pathogen Plectosphaerella cucumerina BMM, the bacterium Pseudomonas syringae pv. tomato DC3000 and the oomycete Hyaloperonospora arabidopsidis Noco2. Remarkably, we found that some of these peptides contribute to Arabidopsis immunity since ePEPs mutants showed enhanced susceptibility to these pathogens. ER-YDA define a novel immune pathway that orchestrates broad-spectrum resistance by regulating defensive responses that act in parallel to canonical disease resistance pathways. We propose that plants evolutionarily co-opted the ER-YDA pathway to generate a novel immune surveillance system linked to stomata development, since these plant apertures are pathogen entry points.
Internacional
Si
Nombre congreso
Plant Peptides & Receptors 2016
Tipo de participación
970
Lugar del congreso
Bischoffsheim,+France
Revisores
Si
ISBN o ISSN
0000-0000
DOI
Fecha inicio congreso
31/08/2016
Fecha fin congreso
02/09/2016
Desde la página
0
Hasta la página
0
Título de las actas
Plant Peptides & Receptors 2016
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Sanjay Swami . (UPM)
  • Autor: Lucia Jorda Miro (UPM)
  • Autor: Sara Sopeña Torres (UPM)
  • Autor: Clara Sánchez Rodríguez (UPM)
  • Autor: Viviana Pamela Escudero Welsch (UPM)
  • Autor: Yangnan Go
  • Autor: Antonio Molina Fernandez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Biotecnología - Biología Vegetal
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