Memorias de investigación
Artículos en revistas:
Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis
Año:2018
Áreas de investigación
  • Biomedicina,
  • Biología,
  • Imágenes médicas,
  • Análisis de imágenes de rango,
  • Procesamiento de imágenes
Datos
Descripción
The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions. The novel pipeline was applied in the analysis of the coronary microvasculature from healthy tissue and tissue at various stages after myocardial infarction (MI) in the pig model, whose coronary vasculature closely resembles that of human tissue. We unravelled alterations in the microvasculature, particularly structural changes and angioadaptation in the aftermath of MI. In addition, we evaluated the extracted knowledge?s potential for the prediction of pathophysiological conditions in tissue, using different classification schemes. The high accuracy achieved in this respect, demonstrates the ability of our approach not only to quantify and identify pathology-related changes of microvascular beds, but also to predict complex and dynamic microvascular patterns.
Internacional
Si
JCR del ISI
Si
Título de la revista
Scientific Reports
ISSN
2045-2322
Factor de impacto JCR
4,259
Información de impacto
Datos JCR del año 2016
Volumen
8
DOI
10.1038/s41598-018-19758-4
Número de revista
Desde la página
1854
Hasta la página
1854
Mes
ENERO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Polyxeni Gkontra . UPM
  • Autor: Kerri-Ann Norton Johns Hopkins University
  • Autor: Magdalena M. Zak Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
  • Autor: Cristina Clemente Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
  • Autor: Jaume Agüero Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
  • Autor: Borja Ibáñez Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
  • Autor: Andres de Santos Lleo UPM
  • Autor: Aleksander S. Popel Johns Hopkins University
  • Autor: Alicia Garcia Arroyo Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
  • Centro o Instituto I+D+i: Centro de I+d+i en Procesado de la Información y Telecomunicaciones
  • Departamento: Ingeniería Electrónica