Descripción
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tIn this work we demonstrate the advantage of performing the biosensing process of a refractive indexoptical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid.We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs)arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPsin dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed asignificant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions,leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These resultsare also in good correlation with 3D-Finite difference time domain simulations carried out for both fluidconditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis willimprove the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops ofbiological samples, in dry conditions, will be a relevant issue for Point of Care Devices | |
Internacional
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Si |
JCR del ISI
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Si |
Título de la revista
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Sensors And Actuators B-Chemical |
ISSN
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0925-4005 |
Factor de impacto JCR
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4,758 |
Información de impacto
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Datos JCR del año 2015 |
Volumen
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DOI
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10.1016/j.snb.2017.11.029 |
Número de revista
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Desde la página
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956 |
Hasta la página
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962 |
Mes
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NOVIEMBRE |
Ranking
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