Memorias de investigación
Artículos en revistas:
The challenge of mapping the human connectome based on diffusion tractography
Año:2017
Áreas de investigación
  • Equipo médico,
  • Tecnología electrónica y de las comunicaciones,
  • Equipo electrónico
Datos
Descripción
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations
Internacional
Si
JCR del ISI
Si
Título de la revista
Nature Communications
ISSN
2041-1723
Factor de impacto JCR
12,124
Información de impacto
Volumen
8
DOI
10.1038/s41467-017-01285-x
Número de revista
Desde la página
1
Hasta la página
13
Mes
NOVIEMBRE
Ranking
Lugar en el Área ?Multidisciplinary Sciences?: 3/64 (D1)
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Klaus Maier-Hein
  • Autor: Peter Neher
  • Autor: Oscar Esteban Sanz-Dranguet UPM
  • Autor: Maxime Descoteaux
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas