Observatorio de I+D+i UPM

Descripción
Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been reported that circRNA can function as microRNA (miRNA) sponges, transcriptional regulators, or potential biomarkers. The availability of massive non-polyadenylated transcriptomes data has facilitated the genome-wide identification of thousands of circRNAs. Several circRNA detection tools or pipelines have recently been developed, and it is essential to provide useful guidelines on these pipelines for users, including a comprehensive and unbiased comparison. Here, we provide an improved and easy-to-use circRNA read simulator that can produce mimicking backsplicing reads supporting circRNAs deposited in CircBase.
Internacional	Si
JCR del ISI	Si
Título de la revista	Plos Computational Biology
ISSN	1553-734X
Factor de impacto JCR	4,542
Información de impacto
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DOI
Número de revista
Desde la página	687
Hasta la página	695
Mes	SIN MES
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Esta actividad pertenece a memorias de investigación

• Autor: Xiangxiang Zeng . (UPM)
• Autor: Wei Lin
• Autor: Maozu Guo
• Autor: Quan Zou

• Creador: Grupo de Investigación: Grupo de Inteligencia Artificial (LIA)
• Departamento: Inteligencia Artificial