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Descripción
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| Introduction Intense endurance exercise produces inflammation and IL-6 elevation, which seems to be one of the most powerful factors up-regulating hepcidin levels (1). Nevertheless, this fact can be conditioned by body ferritin levels prior to exercise (2). In addition, sexual hormones may also influence hepcidin response (1). The purpose of this study is to compare the influence of serum ferritin status and menstrual cycle phases over iron, hepcidin and IL-6 regulation in endurance female athletes. Methods Fifteen endurance trained females (35.5±4 yrs; 58.1±5.6 kg; 163.9±5.9 cm; 50.5±3.7 VO2max) performed a maximal graded test and three continuous running sessions of 40 min at 75% of the VO2max velocity throughout different phases of the menstrual cycle (early follicular phase=EFP, mid follicular phase=MFP and luteal phase=LP). Blood samples were taken pre-exercise, 0h and 3h post exercise. Ferritin levels were measured pre-exercise, whereas iron, IL-6 and hepcidin levels were measured in all samples. Two groups were set depending on ferritin status: <20 µg/L (F1) and ?20 µg/L (F2). Results Mix linear model showed lower iron levels (p=0.004) for F1 (54.1±8.5 µg/dl) than F2 (91.1±8.7 µg/dl), whereas differences between groups for IL-6 and hepcidin were not observed (p>0.05). Menstrual phase and ferritin group interaction presented differences only for iron concentrations (p=0.005). F1 showed lower levels (p=0.07) in EFP (41.7±9.8 µg/dl) than LP (66±10.2 µg/dl), while F2 presented lower levels in EFP (74.76±10.3 µg/dl) than MFP (100.2±9.9 µg/dl; p=0.01) and LP (98.2±10.3 µg/dl; p=0.08). Conclusion Menstrual phase showed lower iron levels during EFP as expected due to menstrual bleeding (1). Our results did not show differences between ferritin groups for hepcidin and IL-6, contrary to previous studies (2). These differences could be due to the fact that our study sample was only women, instead of men or both genders. Despite some studies have reported oestrogen and progesterone influence on hepcidin and IL-6 levels, no differences for hepcidin and IL-6 were found along menstrual cycle phases. These studies tested sexual hormones influence in animals, in vitro, isolated or with supranatural doses, which is far away from a natural menstrual cycle (1). Summing up, it seems that female¿s iron metabolism response to endurance exercise at different ferritin status is similar, although further investigation need to be performed to clarify sexual hormone influence over iron regulation. References 1. Sangkhae V, Nemeth E. Adv Nutr 2017;8(1):126?36. 2. Peeling P, Sim M, Badenhorst CE, Dawson B, Govus AD, Abbiss CR, et al. PLoS One. 2014;9(3). | |
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Internacional
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Si |
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Nombre congreso
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European Congress of Sport Science XXIII |
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Tipo de participación
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960 |
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Lugar del congreso
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Dublín, República de Irlanda |
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Revisores
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Si |
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ISBN o ISSN
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978-3-9818414-1-1 |
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DOI
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Fecha inicio congreso
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04/07/2018 |
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Fecha fin congreso
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07/07/2018 |
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Desde la página
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620 |
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Hasta la página
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620 |
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Título de las actas
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23rd Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE 4th - 7th July 2018, Dublin ? Ireland BOOK OF ABSTRACTS |