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Memorias de investigación
Artículos en revistas:
Supervoxels-Based Histon as a New Alzheimer's Disease Imaging Biomarker (Factor de impacto: 2,475. Cuartil: Q2 (mitad superior))
Año:2018
Áreas de investigación
  • Ingenierías,
  • Imágenes médicas
Datos
Descripción
Alzheimer's disease (AD) represents the prevalent type of dementia in the elderly, and is characterized by the presence of neurofibrillary tangles and amyloid plaques that eventually leads to the loss of neurons, resulting in atrophy in specific brain areas. Although the process of degeneration can be visualized through various modalities of medical imaging and has proved to be a valuable biomarker, the accurate diagnosis of Alzheimer's disease remains a challenge, especially in its early stages. In this paper, we propose a novel classification method for Alzheimer's disease/cognitive normal discrimination in structural magnetic resonance images (MRI), based on the extension of the concept of histons to volumetric images. The proposed method exploits the relationship between grey matter, white matter and cerebrospinal fluid degeneration by means of a segmentation using supervoxels. The calculated histons are then processed for a reduction in dimensionality using principal components analysis (PCA) and the resulting vector is used to train an support vector machine (SVM) classifier. Experimental results using the OASIS-1 database have proven to be a significant improvement compared to a baseline classification made using the pipeline provided by Clinica software.
Internacional
Si
JCR del ISI
Si
Título de la revista
Sensors
ISSN
1424-8220
Factor de impacto JCR
2,475
Información de impacto
Volumen
18
DOI
10.3390/s18061752
Número de revista
6
Desde la página
1
Hasta la página
18
Mes
MAYO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Cesar Antonio Ortiz Toro (UPM)
  • Autor: Consuelo Gonzalo Martin (UPM)
  • Autor: Angel Garcia-Pedrero (Univ. de Valladolid)
  • Autor: Ernestina Menasalvas Ruiz (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Arquitectura y Tecnología de Sistemas Informáticos
  • Departamento: Lenguajes y Sistemas Informáticos e Ingeniería de Software
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